Systemic lupus erythematosus

Correct Answer - T F F T T

Systemic lupus erythematosus is an autoimmune disease characterized by acute and chronic inflammation of various tissues of the body.It is more common in women than men (about eight times more common) especially between the ages of 15 and 50.

  1. Common initial and chronic complaints include fever, malaise, joint pains, myalgias, and fatigue and photosensitive rash
  2. Dermatological manifestations - classic malar rash (or butterfly rash),Alopecia
  3. Musculoskeletal manifestations - Arthralgia and arthritis(small joints of the hand and wrist usually affected)
  4. Hematological manifestations - Pancytoppenia
  5. Cardiac manifestations - Pancarditis,valvular heart diseases
  6. Renal involvement - membranous glomerulonephritis
  7. Neurological manifestations - lupus headache,cognitive dysfunction, mood disorder, Strokes, seizures, polyneuropathy
  8. SLE in a pregnant mother increases the risk of spontaneous abortion, intrauterine fetal death, preeclampsia, intrauterine growth retardation, preterm birth and Neonatal lupus.
  9. Neonatal lupus manifests as congenital heart block or as lupus rash.It is rare in SLE pregnancies.Anti-Ro and anti-La antibodies (for the risk assessment of neonatal lupus) should be performed before pregnancy.

Antinuclear antibody (ANA) testing is the mainstay of serologic testing for SLE. sensitivity = 99%; specificity = 49%

Anti-dsDNA antibodies are highly specific for SLE; they are present in 70% of cases

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